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Proceedings of the National Academy of Sciences of the United States of America

Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP.


PMID 28607054

Abstract

Diverse organisms secrete redox-active antibiotics, which can be used as extracellular electron shuttles by resistant microbes. Shuttle-mediated metabolism can support survival when substrates are available not locally but rather at a distance. Such conditions arise in multicellular communities, where the formation of chemical gradients leads to resource limitation for cells at depth. In the pathogenic bacterium

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