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Proceedings of the National Academy of Sciences of the United States of America

RNA target profiles direct the discovery of virulence functions for the cold-shock proteins CspC and CspE.


PMID 28611217

Abstract

The functions of many bacterial RNA-binding proteins remain obscure because of a lack of knowledge of their cellular ligands. Although well-studied cold-shock protein A (CspA) family members are induced and function at low temperature, others are highly expressed in infection-relevant conditions. Here, we have profiled transcripts bound in vivo by the CspA family members of