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Drug and alcohol dependence

HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens.


PMID 28623807

Abstract

HIV-1 infection and drug abuse are frequently co-morbid and their association greatly increases the severity of HIV-1-induced neuropathology. While nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little is known about how HIV-1 infection affects NAcc. We used calcium and voltage imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat) on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates intracellular Ca We provide evidence that Tat triggers a Ca We describe for the first time a HIV-1 Tat-triggered Ca

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