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Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry

Surface modification minimizes the toxicity of silver nanoparticles: an in vitro and in vivo study.


PMID 28643149

Abstract

Currently toxicological research in Silver nanoparticle is a leading issue in medical science. The surface chemistry and physical dimensions of silver nanoparticles (Ag-NPs) play an important role in toxicity. The aim of this present study was to evaluate the in vitro and in vivo toxicity of Ag-NPs as well as the alteration of toxicity profile due to surface functionalization (PEG and BSA) and the intracellular signaling pathways involved in nanoparticles mediated oxidative stress and apoptosis in vitro and in vivo system. Ag-NPs released excess Ag