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FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Keratins regulate β-cell mitochondrial morphology, motility, and homeostasis.


PMID 28666985

Abstract

Loss of the epithelial intermediate filament protein keratin 8 (K8) in murine β cells leads to irregular insulin vesicles and decreased insulin levels. Because mitochondria are central in glucose-stimulated insulin secretion, the relationship between keratins and β-cell mitochondrial function and morphology was investigated. β cells in murine K8-knockout (K8