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Integrative biology : quantitative biosciences from nano to macro

The Arp2/3 complex binding protein HS1 is required for efficient dendritic cell random migration and force generation.


PMID 28678266

Abstract

Dendritic cell migration to the T-cell-rich areas of the lymph node is essential for their ability to initiate the adaptive immune response. While it has been shown that the actin cytoskeleton is required for normal DC migration, the role of many of the individual cytoskeletal molecules is poorly understood. In this study, we investigated the contribution of the Arp2/3 complex binding protein, haematopoietic lineage cell-specific protein 1 (HS1), to DC migration and force generation. We quantified the random migration of HS1