EMAIL THIS PAGE TO A FRIEND

Frontiers in pharmacology

Embryo and Developmental Toxicity of Cefazolin Sodium Impurities in Zebrafish.


PMID 28694779

Abstract

Cefazolin sodium is an essential drug that is widely used in clinical therapy for certain infective diseases caused by bacteria. As drug impurities are considered to be one of the most important causes of drug safety issues, we studied embryotoxicity, cardiotoxicity, and neurotoxicity of nine cefazolin sodium impurities in zebrafish embryo and larvae for the objective control of impurity profiling. LC-MS/MS was employed to analyze the compound absorbance