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The Journal of neuroscience : the official journal of the Society for Neuroscience

Analysis of RIM Expression and Function at Mouse Photoreceptor Ribbon Synapses.


PMID 28701482

Abstract

RAB3A-interacting molecule (RIM) proteins are important regulators of transmitter release from active zones. At conventional chemical synapses, RIMs contribute substantially to vesicle priming and docking and their loss reduces the readily releasable pool of synaptic vesicles by up to 75%. The priming function of RIMs is mediated via the formation of a tripartite complex with Munc13 and RAB3A, which brings synaptic vesicles in close proximity to Ca