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Frontiers in molecular neuroscience

The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.


PMID 28713240

Abstract

The degeneration of dopaminergic neurons during Parkinson's disease (PD) is intimately linked to malfunction of α-synuclein (αSyn), the main component of the proteinaceous intracellular inclusions characteristic for this pathology. The cytotoxicity of αSyn has been attributed to disturbances in several biological processes conserved from yeast to humans, including Ca