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Neuropsychobiology

The anxiolytic but not the sedative properties of tracazolate are reversed by the benzodiazepine receptor antagonist, Ro 15-1788.


PMID 2872613

Abstract

The effects of the novel putative anxiolytic, tracazolate, were investigated in the social interaction of anxiety and the holeboard. Tracazolate (5 mg/kg) had an anxiolytic action that was no longer observed at higher doses (10-25 mg/kg); in the holeboard tracazolate produced a dose-related (5-25 mg/kg) depression of exploratory head-dipping, locomotor activity and rearing. The effects of tracazolate in the social interaction test, but not in the holeboard, could be reversed by the benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg).