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Virology

Modeling the evolution of SIV sooty mangabey progenitor virus towards HIV-2 using humanized mice.


PMID 28750321

Abstract

HIV-2 is thought to have originated from an SIV progenitor native to sooty mangabeys. To model the initial human transmission and understand the sequential viral evolution, humanized mice were infected with SIVsm and serially passaged for five generations. Productive infection was seen by week 3 during the initial challenge followed by chronic viremia and gradual CD4