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Journal of cell science

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-β.


PMID 28760925

Abstract

Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrP