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Biochimica et biophysica acta

On the quest for the elusive mechanism of action of daptomycin: Binding, fusion, and oligomerization.


PMID 28844744

Abstract

Daptomycin, sold under the trade name CUBICIN, is the first lipopeptide antibiotic to be approved for use against Gram-positive organisms, including a number of highly resistant species. Over the last few decades, a number of studies have tried to pinpoint the mechanism of action of daptomycin. These proposed modes of action often have points in common (e.g. the requirement for Ca