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Brain, behavior, and immunity

A novel role for osteopontin in macrophage-mediated amyloid-β clearance in Alzheimer's models.


PMID 28860067

Abstract

Osteopontin (OPN), a matricellular immunomodulatory cytokine highly expressed by myelomonocytic cells, is known to regulate immune cell migration, communication, and response to brain injury. Enhanced cerebral recruitment of monocytes achieved through glatiramer acetate (GA) immunization or peripheral blood enrichment with bone marrow (BM)-derived CD115