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European journal of medicinal chemistry

Synthesis, in vitro β-glucuronidase inhibitory potential and molecular docking studies of quinolines.


PMID 28865280

Abstract

In this study synthesis and β-glucuronidase inhibitory potential of 3/5/8 sulfonamide and 8-sulfonate derivatives of quinoline (1-40) are discussed. Studies reveal that all the synthetic compounds were found to have good inhibitory activity against β-glucuronidase. Nonetheless, compounds 1, 2, 5, 13, and 22-24 having IC