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Proceedings of the National Academy of Sciences of the United States of America

Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.


PMID 28874589

Abstract

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT