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Neurobiology of aging

A role of BAG3 in regulating SNCA/α-synuclein clearance via selective macroautophagy.


PMID 28941726

Abstract

Many studies reveal that BAG3 plays a critical role in the regulation of protein degradation via macroautophagy. However, it remains unknown whether BAG3 affects the quality control of α-synuclein (SNCA), a Parkinson's disease-related protein. In this study, we demonstrated the increases of BAG3 expression in the ventral midbrain of SNCA