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Journal of cell science

Kindlin supports platelet integrin αIIbβ3 activation by interacting with paxillin.


PMID 28954813

Abstract

Kindlins play an important role in supporting integrin activation by cooperating with talin; however, the mechanistic details remain unclear. Here, we show that kindlins interacted directly with paxillin and that this interaction could support integrin αIIbβ3 activation. An exposed loop in the N-terminal F

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P0115
PAC-1, ≥98% (HPLC)
C23H28N4O2