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Oncotarget

Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation.


PMID 28968975

Abstract

Glioblastomas are among the most fatal brain tumors; however, the molecular determinants of their tumorigenic behavior are not adequately defined. In this study, we analyzed the role of KMT2A in the glioblastoma cell line U-87 MG. KMT2A knockdown promoted cell proliferation. Moreover, it increased the DNA methylation of