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Cell death & disease

Differential regulation of spermatogenic process by Lkb1 isoforms in mouse testis.


PMID 29022902

Abstract

Liver serine/threonine kinase B1 (LKB1) is a tumor suppressor associated with the pathogenesis of Peutz-Jeghers syndrome. Affected males are at increased risk of developing Sertoli cell tumors and display defective spermatogenesis. Male mice lacking the short isoform (Lkb1

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