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Oncotarget

Exostosin 1 regulates cancer cell stemness in doxorubicin-resistant breast cancer cells.


PMID 29050299

Abstract

Cancer stem cells (CSCs) are associated with cancer recurrence following radio/chemotherapy owing to their high resistance to therapeutic intervention. In this study, we investigated the role of exostoxin 1 (EXT1), an endoplasmic reticulum (ER)-residing type II transmembrane glycoprotein, in cancer cell stemness. DNA microarray analysis revealed that doxorubicin-resistant MCF7/ADR cells have high levels of EXT1 expression compared to its parental cell line, MCF7. These cells showed significantly higher populations of CSCs and larger populations of aldehyde dehydrogenase (ALDH

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EHU007581 MISSION® esiRNA, esiRNA targeting human EXT1 (esiRNA1)