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Pharmacological reports : PR

Role of thalamic ventral posterolateral nucleus histamine H


PMID 29145067

Abstract

Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide cannulas. Muscle pain was induced by intramuscular injection of a diluted formalin solution (2.5%, 50μl) into the belly of gastrocnemius muscle, and pain-related behaviors including paw licking duration and paw flinching number were recorded at five-min blocks for 60min. Formalin produced a biphasic pattern of pain-related behaviors. Ranitidine (a histamine H Our results showed an interaction between histamine H

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