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Stem cell research & therapy

Calcium-containing scaffolds induce bone regeneration by regulating mesenchymal stem cell differentiation and migration.


PMID 29145866

Abstract

Osteoinduction and subsequent bone formation rely on efficient mesenchymal stem cell (MSC) recruitment. It is also known that migration is induced by gradients of growth factors and cytokines. Degradation of Ca A circular calvarial bone defect (5 mm diameter) was created in the parietal bone of 35 Balb-C mice. We prepared and implanted a cell-free agarose/gelatin scaffold alone or in combination with different CaSO CaSO Specific CaSO