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Experimental cell research

miR-195 inhibited abnormal activation of osteoblast differentiation in MC3T3-E1 cells via targeting RAF-1.


PMID 29197556

Abstract

Recent reports have demonstrated that RAF-1 To demonstrate that RAF-1 is associated with bone deformity and that RAF-1 RAF-1, especially RAF-1 Our findings indicated that miR-195 inhibited WT and L613V RAF-1 induced hyperactive osteoblast differentiation in MC3T3-E1 cells by targeting RAF-1. miR-195 might be a novel therapeutic agent for the treatment of L613V-induced bone deformity in Noonan syndrome.