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American journal of translational research

Rational lung tissue and animal models for rapid breath tests to determine pneumonia and pathogens.


PMID 29218109

Abstract

This study works to develop novel models that may be adopted for earlier non-invasive breathomics tests to determine pneumonia pathogens. Two types of pneumonia models were created, both Pneumonia and pathogen-specific discriminating VOC patterns (1H-Pyrrole-3-carbonitrile, Diethyl phthalate, Cedrol, Decanoic acid, Cyclohexane, Diisooctyl phthalate) were determined. Our study successfully generated nosocomial pneumonia models for pneumonia diagnosis and pathogen-discriminating breath tests. The tests may allow for earlier pneumonia and pathogen diagnoses, and may transfer empirical therapy to targeted therapy earlier, thus improving clinical outcomes.