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Pakistan journal of pharmaceutical sciences

Synthesis and antibacterial activity of the sulfonamide based schiff base and its transition metal (II) complexes.


PMID 29348091

Abstract

A Schiff base 3 has been synthesized by equimolar reaction (condensation) of sulfonamide i.e. sulfamethoxypyridazine 1 and substituted aromatic aldehyde i.e. 2-Hydroxy-1-Napthalene aldehyde 2. The synthesized Schiff base 3 and its Metal (II) complexes were characterized by its physical, analytical (CHN analysis) and spectral (UV & IR) analysis. The Staphylococcus aureus and Escherichia coli bacterial strains were used for antibacterial activity of Sulfamethoxypyridazine 1, its Schiff base 3 and its transition metal (II) complexes 4-8. All of them showed varied levels of activity.