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Oncotarget

Inactivation/deficiency of DHODH induces cell cycle arrest and programed cell death in melanoma.


PMID 29348830

Abstract

Malignant melanoma (MM) is one of the most malignant tumors and has a very poor prognosis. However, there are no effective drugs to treat this disease. As a kind of iron flavin dependent enzyme, dihydroorotate dehydrogenase (DHODH, EC 1.3.3.1) is the fourth and a key enzyme in the