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Proceedings of the National Academy of Sciences of the United States of America

Increased thermogenesis by a noncanonical pathway in ANGPTL3/8-deficient mice.


PMID 29358393

Abstract

Dietary triglyceride (TG) is the most efficient energy substrate. It is processed and stored at substantially lower metabolic cost than is protein or carbohydrate. In fed animals, circulating TGs are preferentially routed for storage to white adipose tissue (WAT) by angiopoietin-like proteins 3 (A3) and 8 (A8). Here, we show that mice lacking A3 and A8 (