EMAIL THIS PAGE TO A FRIEND

Nature methods

Chemogenetic control of gene expression and cell signaling with antiviral drugs.


PMID 29967495

Abstract

We developed a method in which the NS3 cis-protease from hepatitis C virus can be used as a ligand-inducible connection to control the function and localization of engineered proteins in mammalian cells. To demonstrate the versatility of this approach, we designed drug-sensitive transcription factors and transmembrane signaling proteins, the activities of which can be tightly and reversibly controlled through the use of clinically tested antiviral protease inhibitors.

Related Materials