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Brain research

Absence of decarboxylation of some aromatic-L-amino acids by cultured astrocytes.


PMID 3121134

Abstract

The addition of L-3,4-dihydroxyphenylalanine, L-5-hydroxytryptophan or m-tyrosine to cultured isolated astrocytes does not elicit the synthesis of either dopamine, 5-hydroxytryptamine or m-tyramine, respectively. In contrast, the astrocytes show ability to take up and store dopamine and 5-hydroxytryptamine that are in turn respectively metabolized to 3,4-dihydroxyphenylacetic acid or 5-hydroxyindoleacetic acid. These findings suggest that astroglial cell cultures lack aromatic-L-amino acid decarboxylase and give further evidence that these cells contain monoamine oxidase.