EMAIL THIS PAGE TO A FRIEND

Experimental eye research

Kinetic effects of metal ion chelating reagents and their analogues on bovine lens aldehyde dehydrogenase.


PMID 3622646

Abstract

The chelating agents 1,10-phenanthroline and 2,2'-dipyridyl gave partial inhibition of the bovine lens aldehyde dehydrogenase, which was fully reversible and competitive towards acetaldehyde. The non-chelating compounds, 1,7-phenanthroline, 4,7-phenanthroline and 4,4'-dipyridyl gave total competitive inhibition, and significant activation at saturating substrate and coenzyme concentrations, in a manner similar to cyanide. All five isomers prevented the binding of the coenzyme NAD+, the non-chelating phenanthroline compounds being the most effective. An overall mechanism for inhibition by single and bidentate ligands is proposed.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

301868
4,7-Phenanthroline, 98%
C12H8N2