EMAIL THIS PAGE TO A FRIEND

Science (New York, N.Y.)

Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.


PMID 3883489

Abstract

Glutathione reductase from trypanosomes and leishmanias, unlike glutathione reductase from other organisms, requires an unusual low molecular weight cofactor for activity. The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-spermidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed. This discovery may open a new chemotherapeutic approach to trypanosomiasis and leishmaniasis.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

04555
Trypanothione trifluoroacetate salt, ≥98% (HPLC)
C27H47N9O10S2 · xC2HF3O2