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Journal of neurology, neurosurgery, and psychiatry

Elevated levels of free putrescine and N1-acetylspermidine in cyst fluids of malignant brain tumours.


PMID 3950641

Abstract

The contents of free and conjugated polyamines in cyst fluids of brain tumours were analysed. The putrescine and N1-acetylspermidine levels in cyst fluids of malignant brain tumours were significantly higher than those of benign tumours. The free spermidine levels in malignant and benign tumours were about the same, while the total spermidine levels were higher in malignant than those in benign tumours. These results suggest that polyamine levels in cyst fluids reflect the altered polyamine metabolism in brain tumours.