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Proceedings of the National Academy of Sciences of the United States of America

Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture.


PMID 4186808

Abstract

Tissue culture cells of a Rous virus-induced rat tumor undergo syncytium formation when placed in contact with mouse embryo cell cultures infected with murine leukemia viruses. This phenomenon can be used as a cytopathic end point for isolating and titrating these viruses in tissue culture. The principle should be applicable to detection of leukemia viruses of other species.

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