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Science (New York, N.Y.)

Hydroxylase cofactor activity in cerebrospinal fluid of normal subjects and patients with Parkinson's disease.


PMID 432666

Abstract

A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrsopinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed.