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Alprazolam: a review of its pharmacodynamic properties and efficacy in the treatment of anxiety and depression.


PMID 6141930

Abstract

Alprazolam is a triazolobenzodiazepine which is related to diazepam and other 1,4-benzodiazepines, and has a similar pharmacological profile. Relative to the newer benzodiazepines, alprazolam has an intermediate half-life of 10 to 12 hours in healthy young subjects. In placebo-controlled and double-blind comparative trials in patients with anxiety, alprazolam was of comparable efficacy to diazepam and generally caused a lower incidence of drowsiness. Alprazolam has antidepressant activity and has been shown to be similar in efficacy to imipramine in the treatment of unipolar depression. Thus, alprazolam may be particularly useful in patients with mixed anxiety/depression. However, its general acceptance as an antidepressant awaits further studies.

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Molecular Formula

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A8800
Alprazolam
C17H13ClN4
1015008
Alprazolam, United States Pharmacopeia (USP) Reference Standard
C17H13ClN4