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European journal of biochemistry

A synthetic ionophore for Ca2+: studies with model and biological systems.


PMID 6169522

Abstract

We show that the relatively simple beta-diketone, 1.1.1.2.2.3.3-heptafluoro-7,7-dimethyloctane-4,6-dione, known as "fod", will solvate Ca2+ ions in an organic phase. In consequence it will transport Ca2+ across phospholipid bilayers. It acts as predicted for a Ca2+-transporting ionophore in two biological systems: it will stimulate Ca2+-dependent K+ efflux from human red blood cells, and Ca2+-dependent histamine secretion from rat peritoneal mast cells.

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175161
6,6,7,7,8,8,8-Heptafluoro-2,2-dimethyl-3,5-octanedione, 98%
C10H11F7O2