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Clinical chemistry

The chemical basis and specificity of the nitrosonaphthol reaction.


PMID 6194918

Abstract

1-Nitroso-2-naphthol reacts with various 5-hydroxyindoles as well as para-substituted phenols and guaiacols. Consequently, this reaction has long been used to measure tyrosine in tyrosinosis and tyrosinemia, homovanillic acid in neuroblastoma, and 5-hydroxy-3-indoleacetic acid in the carcinoid tumor. We report here on the specificity of this reaction, as well as our early observations with respect to the chemical basis of the reaction.

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114693
1-Nitroso-2-naphthol, 97%
C10H7NO2