EMAIL THIS PAGE TO A FRIEND

Nature

A new class of angiotensin-converting enzyme inhibitors.


PMID 6253826

Abstract

Much current attention focuses on the renin-angiotensin system in relation to mechanisms controlling blood pressure and renal function. Recent demonstrations (ref. 1, ref. 2 and refs therein) that angiotensin-converting enzyme inhibitors show promising clinical antihypertensive properties have been of particular interest. We now report on the design of a novel series of substituted N-carboxymethyl-dipeptides which are active in inhibiting angiotensin-converting enzyme at nanomolar levels. We suggest that these compounds are transition-state inhibitors and that extensions of this design to other metalloendopeptidases merit further study.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

L2777 Lisinopril, ACE Inhibitor