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Histochemistry

Cytochemical demonstrations of protease in human peripheral blood cells by use of new alpha-naphthyl ester substrates.


PMID 6408033

Abstract

The proteases of human leukocytes were cytochemically studied by use of new alpha-naphthyl esters, tosyl-L-lysine-alpha-naphthyl ester (TLNE) and acetyl-L-tyrosine-alpha-naphthyl ester (ATNE). The hydrolytic activities were strong only in neutrophils, with both substrates. They were inhibited completely by DFP and chymostatin, but not by leupeptin and iodoacetate. These results indicate that chymotrypsin-like enzyme(s), capable of hydrolyzing both substrates, exist in neutrophils.

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N8000
1-Naphthyl butyrate, esterase substrate
C14H14O2