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International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

Quantitative and qualitative effects of N10-methylfolate on high-affinity folate binding in human leukocytes.


PMID 6500843

Abstract

N10-methylfolate acted as a potent competitive inhibitor of high-affinity [3H] folate binding in human leukocytes, while methotrexate had no effect. Furthermore, folate binding changed into a non-cooperative type in the presence of N10-methylfolate. Hence, in qualitative and quantitative respects, the substrate specificity characteristics of leukocyte folate binding resemble those of other high-affinity folate binding systems.

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Y0000663 Methotrexate impurity C, European Pharmacopoeia (EP) Reference Standard
C20H21N7O6