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Journal of applied toxicology : JAT

Comparative effects of various lead salts on delayed hypersensitivity in mice.


PMID 6512164

Abstract

Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell-mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.