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Biomaterials, medical devices, and artificial organs

Surface modification of polycarbonate with synthetic polyelectrolyte-anticoagulant activity.


PMID 6537263

Abstract

Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded polyelectrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity. This might be due to the presence of both sulfamate and carboxylate groups arranged in a steric manner in the molecule as that of Heparin. Surface energy parameters, platelet adhesion and plasma recalcification time were investigated. Possible comparison with heparin had been demonstrated.

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