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Problemy endokrinologii

[Comparative study of the effectiveness of various doses of estrogens after their "central" and "peripheral" administration].


PMID 6647433

Abstract

Experiments on male rats were made to study the effects of synestrol and diethylstilbestrol on the sexual organs. The drugs were administered subcutaneously and into the CSF. Diethylstilbestrol propionate produced the most potent inhibitory action on proliferative processes in the prostate. This inhibition was found to be the most demonstrable when the drug was administered into the CSF. During endo-CSF administration the dose of the hormone could be considerably decreased, with the inhibitory action on the target organs being unchanged and side effects on the animal body being minimal.

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D3881
Diethylstilbestrol dipropionate, analytical standard, for drug analysis
C24H28O4