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Proceedings of the National Academy of Sciences of the United States of America

A nondenaturing zwitterionic detergent for membrane biochemistry: design and synthesis.


PMID 6935651

Abstract

The synthesis and evaluation of a new detergent that is a zwitterionic derivative of cholic acid is presented. This detergent combines the useful properties of both the sulfobetaine-type detergents and the bile salt anions. The new detergent proved to be effective at solubilizing membrane proteins in a nondenatured state.