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Pathologie-biologie

[Effects of arginine aspartate when administered orally, upon nitrogen balance of the rabbit, normal or treated by glucocorticoids (author's transl)].


PMID 7045779

Abstract

A nitrogen balance study is performed upon young male rabbit, non treated or treated with glucocorticoids (hydrocortisone : 15 mg a day for 18 days). Arginine aspartate, when administered daily "per os" at fast, 1 500 mg/kg for 4 days, increases strongly nitrogen retention, in non treated rabbit (p less than 0,01). During the last four days of the glucocorticoids treatment, the product (1 500 mg/kg a day) corrects the decrease (p less than 0,01) of nitrogen balance induced by hydrocortisone. Nitrogen retention appears to be more important (p less than 0,01) than the one induced by hydrocortisone alone, and returns to the non treated rabbit value. Arginine aspartate oral administration can provoke, by the way of stimulation of endogenous growth hormone secretion, a protein anticatabolic effect.