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Biochimica et biophysica acta

The rapid transbilayer movement of thiocholesterol in small unilamellar phospholipid vesicles.


PMID 7260079

Abstract

Cholesterol is a major component of biological membranes, yet there is very little information concerning its distribution across the membrane. Recent experiments in our laboratory, using cholesterol oxidase, have demonstrated that cholesterol can undergo a rapid transbilayer movement in lecithin-cholesterol vesicles in a half-time of 1 min or less at 37 degrees C. In order to support this conclusion, we have sought other approaches to the measurement of this process. We now report our finding that the transbilayer movement of thiocholesterol in phospholipid vesicles occurs in a half-time of 1 min or less at 20 degrees C.

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136115
Thiocholesterol
C27H46S