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Experientia

The effects of triaminopyrimidine on the short circuit current and transmembrane potentials of the isolated rat visceral yolk sac in vitro.


PMID 7379956

Abstract

Intracellular potentials in the cells from 17.5-day old rat visceral yolk sacs were measured by a glass microelectrode. When penetrated from the maternal side, the cells have potentials of about 50.2 +/- 1.9 mV (inside negative) which were reduced by increasing the external K+ concentration and increased by removing Na+ ions from the bathing fluid. Triaminopyrimidine (TAP) which inhibited Na+ transport caused a dose-dependent depolarization of the cell membrane. The depolarization was dependent on the presence of extracellular Ca2+ ions. It is proposed that TAP may inhibit Na+ transport by increasing the intracellular concentration of calcium ions.

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T45802
2,4,6-Triaminopyrimidine, 97%
C4H7N5