EMAIL THIS PAGE TO A FRIEND

Journal of chromatography

Simultaneous quantitation of chlormethiazole and two of its metabolites in blood and plasma by gas--liquid chromatography.


PMID 7380902

Abstract

A simple and rapid gas chromatographic method for the quantitation of chlormethiazole and two of its pharmacologically active metabolites, 5-acetyl-4-methylthiazole and 5-(1-hydroxyethyl)-4-methylthiazole, in plasma and blood is described. The total analysis time is less than 20 min for a single sample. The method requires 50--500 microliter of plasma or 1 ml of blood. The compounds are detected with a nitrogen--phosphorus detector. An internal standard technique is used for the quantitation. Calibration data are linear over the range 32--2376 ng of chlormethiazole and a similar range of the metabolites in plasma. The method may be used for pharmacokinetic studies.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

CBR01086
1-(4-Methyl-1,3-thiazol-5-yl)ethanone, AldrichCPR
C6H7NOS