EMAIL THIS PAGE TO A FRIEND

Nucleic acids research

Solid-phase synthesis of polynucleotides. II. Synthesis of polythymidylic acids by the block coupling phosphotriester method.


PMID 7465418

Abstract

Synthesis of two oligothymidylic acids, tridecamer and nonadecamer, is described by a rapid and simple solid-phase method on two kinds of polyacrylamide supports derivatized from commercially available Enzacryl Gel K-2. The syntheses were performed by the phosphotriester method using di- and tri-thymidylic acid blocks as the incoming 3'-phosphodiester component. High coupling yields were consistently obtained and the final product was isolated very easily by high performance liquid chromatography on Permaphase AAX.

Related Materials

Product #

Image

Description

Molecular Formula

Add to Cart

360139
5′-O-(4,4′-Dimethoxytrityl)thymidine, 98%
C31H32N2O7